Corpus ID: 45619888

Inhibitory activity of 2-aminooxazole derivatives against Coxsackie B1 virus in FL cells.

  title={Inhibitory activity of 2-aminooxazole derivatives against Coxsackie B1 virus in FL cells.},
  author={M. Tonew and E. Tonew},
  journal={Acta virologica},
  volume={24 3},
The antiviral activity of three-2-aminooxazoles was studied against coxsackie B1 virus in FL cells. The virus-induced cytopathic effect was nearly completely suppressed by two of the test compounds as revealed by spectrophotometric turbidity measurements. The plaque reduction amounted to 95--100 per cent. The compounds had no effect on extracellular virus or on absorption and penetration. The inhibition of infectious virus yield in one-step growth experiments reached 94--99.9 per cent. One of… Expand
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Chapter 15. Antiviral Agents
6-azauridine is phosphorylated by uridine kinase to the 5’ monophosphate that acts as a competitive inhibitor of monophosorotidylate (OMP) decarboxylase and was not highly active against pox and herpesviruses in vitro , most experimental animal and human studies have concentrated on these DNA viruses. Expand
Antiviral agents 1978-1983.
  • D. L. Swallow
  • Medicine
  • Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1984
It is the objective of this review to present, from the viewpoint of a medicinal chemist, some of the advances made during the last five years in the search for antiviral agents.