Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells.

A major hallmark of Alzheimer's disease is the cerebral accumulation and resulting cytotoxicity of amyloid-β peptides, particularly Aβ42. In this study, we used an MTT assay to investigate the inhibitory activity of biflavonoids 1-22 against Aβ42 cytotoxicity in PC-12 cell cultures. Cytoprotective effects were observed for the following amentoflavone type… CONTINUE READING