Inhibitory actions of genistein in human breast cancer (MCF-7) cells.

  title={Inhibitory actions of genistein in human breast cancer (MCF-7) cells.},
  author={Wen-Fang Chen and Ming-Hui Huang and Chi-hung Tzang and Mengsu Yang and Man-sau Wong},
  journal={Biochimica et biophysica acta},
  volume={1638 2},
Genistein, a natural isoflavanoid phytoestrogen, is thought to be the active ingredient in soy that possesses breast cancer preventive properties. The molecular mechanisms that are involved in its cancer preventive properties have not been completely understood. The present study is designed to investigate the mechanism involved in the inhibitory action of genistein in MCF-7 cells. Genistein at 50 and 100 microM significantly arrested the growth of MCF-7 cells at G2/M phase (P<0.05) and… CONTINUE READING
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