Inhibitory action of transforming growth factor beta on endothelial cells.

  title={Inhibitory action of transforming growth factor beta on endothelial cells.},
  author={Gertraud M{\"u}ller and J A Behrens and Ute Nussbaumer and Peter B{\"o}hlen and Walter Birchmeier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 16},
In the present study, we show that transforming growth factor beta (TGF-beta) strongly inhibits fibroblast growth factor-induced proliferation and motility of bovine endothelial cells in tissue culture. TGF-beta also prevents the phorbol ester-induced invasion of capillary endothelial cells into collagen matrices--i.e., blocks angiogenesis in vitro. TGF-beta promotes the incorporation of fibronectin into the extracellular matrix of endothelial cells and stimulates the secretion of other… CONTINUE READING


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