Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells.

Abstract

Rat peritoneal mast cells which had been preincubated with phorbol myristate acetate (PMA, 10 - 100 ng/ml) for 5 min did not elicit the full histamine secretion induced by a potent secretagogue, compound 48/80. Furthermore, this PMA-treatment was found to inhibit the agonist-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in [32P]labeled… (More)

Topics

Cite this paper

@article{Okano1985InhibitoryAO, title={Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells.}, author={Y. Okano and H. Takagi and Satoru Nakashima and Touche Tohmatsu and Yoshinori Nozawa}, journal={Biochemical and biophysical research communications}, year={1985}, volume={132 1}, pages={110-7} }