Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.

@article{Sone1983InhibitoryAO,
  title={Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.},
  author={Hiroshi Sone and Issei Takayanagi},
  journal={Journal of pharmacobio-dynamics},
  year={1983},
  volume={6 4},
  pages={
          272-4
        }
}
Newly synthesized compound, 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]acrylonitrile (SX-284) inhibited electrically evoked acetylcholine release from the stores in the myenteric plexus-longitudinal strips of guinea pig ileum which was labelled with [3H]-choline but not the evoked release of tracer from rat vas deferens after labelling with [3H]-norepinephrine. These results support our previous findings that SX-284 specifically inhibit acetylcholine release from the vagus nerve… 
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References

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A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).
TLDR
SX-284 specifically inhibits the acetylcholine release from the vagus nerve, and spontaneous movement of the guinea pig ileum was dose-dependently depressed by SX-284.
The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip
1 Noradrenaline and adrenaline reduce the output of acetylcholine by the guinea‐pig ileum longitudinal strip by up to 80%, both in resting conditions and after stimulation. The effect is graded with