Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum.

@article{Tonini1986InhibitoryAO,
  title={Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum.},
  author={Marcello Tonini and Luciano Onori and Carlo A. Rizzi and Fabrizio De Ponti and Emilio Perucca and P Budassi and Antonio Crema},
  journal={European journal of pharmacology},
  year={1986},
  volume={128 3},
  pages={
          273-6
        }
}

Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum

Results indicate that depression of SP receptor function achieved by three different procedures decreases cholinergic contractile responses to GABAA agonists in the guinea-pig ileum, providing further support for the hypothesis that GAB AA receptor activation evokes both direct and indirect stimulation of entericCholinergic neurons and that SP and/or a related peptide play an important role in mediating the indirect component of the Cholinergic response.

GABAA receptor‐mediated positive inotropism in guinea‐pig isolated left atria: evidence for the involvement of capsaicin‐sensitive nerves

It is concluded that, in the guinea‐pig heart, GABAA receptors, presumably located on the preterminal region of capsaicin‐sensitive sensory nerves, initiate a conducted impulse which leads to transmitter release (endogenous CGRP‐like material) by activation of ω‐conotoxin‐sensitive, voltage‐sensitive calcium channels and a functional response.

The Role of GABA in the Peripheral Nervous System

Evidence from physiological, neurochemical, and morphological studies suggests that GABA acts on peripheral tissues not only as a neurotransmitter in enteric and parasympathetic nervous systems, but additionally as a hormone.

GABA and Gut Motility

This work has shown that isolated segments continue to exhibit a range of motility, including the peristaltic reflex, even when totally removed and maintained in artificial media, and this has formed the basis of the studies on GABA involvement in motility patterns of the gut.

References

SHOWING 1-9 OF 9 REFERENCES

Inhibition of calcium spikes and transmitter release by γ‐aminobutyric acid in the guinea‐pig myenteric plexus

It is concluded that GABA inhibits release of ACh and the transmitter mediating the slow e.p.s.ps evoked by single or repetitive presynaptic nerve stimulation were reduced in amplitude by GABA.

Substance P provoked gamma‐aminobutyric acid release from the myenteric plexus of the guinea‐pig small intestine.

Evidence is provided for the neurotransmitter role of GABA and a possible excitatory role of substance P on the GABAergic neurones in the myenteric plexus of the guinea‐pig small intestine.

Actions of γ‐aminobutyric acid on neurones of guinea‐pig myenteric plexus

It is concluded that GABA has two effects on the membrane of myenteric neurones: the first is a bicuculline‐sensitive, rapidly desensitizing chloride activation and the second is abicuculine‐insensitive, non‐desensitization depolarization.

GABAA and GABAB receptor‐mediated effects in guinea‐pig ileum

It is confirmed that GABA, homotaurine and muscimol are GABAA agonists, while GABA and (—)‐baclofen are GABAB agonists and two receptors mediate the GABA effects in guinea‐pig ileum.