Inhibitory action of Wnt target gene osteopontin on mitochondrial cytochrome c release determines renal ischemic resistance.

@article{Vias2010InhibitoryAO,
  title={Inhibitory action of Wnt target gene osteopontin on mitochondrial cytochrome c release determines renal ischemic resistance.},
  author={Jose Luis Vi{\~n}as and Anna Sola and Michaela Jung and Chrysoula Mastora and Eugenia Vinuesa and Felip Pi and Georgina Hotter},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 1},
  pages={F234-42}
}
Certain determinants of ischemic resistance in the Brown Norway rat strain have been proposed, but no studies to date have focused on the role of the Wnt pathway in the ischemic resistance mechanism. We performed a comparative genomic study in Brown Norway vs. Sprague-Dawley rats. Selective manipulations of the Wnt pathway in vivo and in vitro allowed us to study whether the action of the Wnt pathway on apoptosis through the regulation of osteopontin was critical to the maintenance of inherent… CONTINUE READING
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