Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

Abstract

IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ, is less well understood. One major reason for this is the absence of chemical tools designed as selective inhibitors for IKKα over IKKβ. Herein, we… (More)
DOI: 10.1021/acs.jmedchem.7b00484

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@inproceedings{Anthony2017InhibitoryKB, title={Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers}, author={Nahoum G. Anthony and Jessica Baiget and Giacomo Berretta and M. W. J. Boyd and David S. Breen and J. Adam Edwards and Carly Gamble and Alexander Gray and Alan L. Harvey and Sophia Hatziieremia and Ka Ho Ho and Judith K. Huggan and Stuart Lang and Sabin Llona-Minguez and Jia Lin Luo and Kathryn McIntosh and Andrew Paul and Robin J. Plevin and Murray N Robertson and Rebecca Scott and Colin J. Suckling and Oliver B Sutcliffe and Louise C. Young and Simon P. Mackay}, booktitle={Journal of medicinal chemistry}, year={2017} }