Inhibitory Influence of Agmatine in Ethanol Withdrawal-Induced Depression in Rats: Behavioral and Neurochemical Evidences.

@article{Chimthanawala2019InhibitoryIO,
  title={Inhibitory Influence of Agmatine in Ethanol Withdrawal-Induced Depression in Rats: Behavioral and Neurochemical Evidences.},
  author={Niyamat Chimthanawala and Shruti Patil and Rishabh Agrawal and Nandkishor R Kotagale and Milind Janraoji Umekar and Brijesh Gulabrao Taksande},
  journal={Alcohol},
  year={2019}
}
5 Citations
Effects of imidazoline agents in a rat conditioned place preference model of addiction
TLDR
Assessment of the interaction between AG, IDZ, and EFR with an opiate, tramadol, in a conditioned place preference (CPP) paradigm found that AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in theTR-paired compartment, without statistical significance.

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Inhibition of EtOH sensitization by Agmatine is mediated through imidazoline receptors and project agmatine and imidrazoline agents in the pharmacotherapy of alcohol addiction.
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Data demonstrate that agmatine elicited a significant antidepressant-like effect through a mechanism that seems to involve an interaction with NMDA receptors, the L-arginine-nitric oxide pathway and &agr;2-adrenoceptors.
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