Inhibitory Effects of Leptin on Pancreatic α-Cell Function

Abstract

OBJECTIVE Leptin released from adipocytes plays a key role in the control of food intake, energy balance, and glucose homeostasis. In addition to its central action, leptin directly affects pancreatic beta-cells, inhibiting insulin secretion, and, thus, modulating glucose homeostasis. However, despite the importance of glucagon secretion in glucose… (More)
DOI: 10.2337/db08-1787

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