Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9.

@article{Li2015InhibitoryEO,
  title={Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9.},
  author={Chenglin Li and Dan Yang and Yuanwei Zhao and Yu Qiu and Xin Cao and Yanyan Yu and Hao Guo and Xiaoke Gu and Xiaoxing Yin},
  journal={Nutrition and cancer},
  year={2015},
  volume={67 7},
  pages={1191-200}
}
Matrix metalloproteinases (MMPs) play an active role in facilitating the invasion of cancer cells with excessive extracellular matrix (ECM) degradation. In the present study, we investigated the antiinvasive effects of isorhamnetin, a naturally occurring flavonoid, on MDA-MB-231 human breast carcinoma cells. The results indicated that isorhamnetin significantly inhibited the adhesion, migration, and invasion of the cells in vitro. Moreover, isorhamnetin suppressed the activity and expression of… CONTINUE READING

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