Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats

@inproceedings{Tian2013InhibitoryEO,
  title={Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats},
  author={Xin Tian and Zhen-Yu Cheng and Han Yong Jin and Jie Gao and Hai-Ling Qiao},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2013}
}
Baicalin, a flavonoid compound isolated from Scutellaria baicalensis, has been shown to possess antiinflammatory, antiviral, antitumour, and immune regulatory properties. The present study evaluated the potential herb-drug interaction between baicalin and midazolam in rats. Coadministration of a single dose of baicalin (0.225, 0.45, and 0.90 g/kg, i.v.) with midazolam (10 mg/kg, i.v.) in rats resulted in a dose-dependent decrease in clearance (CL) from 25%  (P < 0.05) to 34%  (P < 0.001) with… CONTINUE READING

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