Inhibitory Effect of Triterpenoids from Dillenia serrata (Dilleniaceae) on Prostaglandin E2 Production and Quantitative HPLC Analysis of Its Koetjapic Acid and Betulinic Acid Contents

@article{Jalil2015InhibitoryEO,
  title={Inhibitory Effect of Triterpenoids from Dillenia serrata (Dilleniaceae) on Prostaglandin E2 Production and Quantitative HPLC Analysis of Its Koetjapic Acid and Betulinic Acid Contents},
  author={J. Jalil and C. W. Sabandar and N. Ahmat and J. A. Jamal and I. Jantan and Nor-Ashila Aladdin and K. Muhammad and Fhataheya Buang and H. F. Mohamad and I. Sahidin},
  journal={Molecules},
  year={2015},
  volume={20},
  pages={3206 - 3220}
}
The crude methanol extracts and fractions of the root and stem barks of Dillenia serrata Thunb. showed 64% to 73% inhibition on the production of prostaglandin E2 (PGE2) in lipopolysaccharide-induced human whole blood using a radioimmunoassay technique. Three triterpenoids isolated from the root bark of the plant, koetjapic (1), 3-oxoolean-12-en-30-oic (2), and betulinic (3) acids, exhibited significant concentration-dependent inhibitory effects on PGE2 production with IC50 values of 1.05, 1.54… Expand
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