Inhibitory Effect of Ginkgo Biloba Extract on the Tonus of the Small Intestine and the Colon of Rabbits

  title={Inhibitory Effect of Ginkgo Biloba Extract on the Tonus of the Small Intestine and the Colon of Rabbits},
  author={Vladimir Pilija and Radenkovic Mirjana and Maja Dj. Djurendi{\'c} Brenesel and Mira Popovi{\'c} and Vesna Iveti{\'c} and Svetlana Trivi{\'c}},
  pages={2079 - 2086}
Ginkgo biloba is widely used in folk medicine. Patients very often use the plant preparation with no concern for purity. They also tend to increase the dosage by themselves and this may result in certain insufficiently researched acute effects. Due to this extremely widespread application, the aim of this work is an examination of the possible acute effects of Ginkgo biloba on the motility of the small and the large intestine of rabbits. Тhe effects of Gingium® - a standardized ginkgo biloba… 
In-vitro and in-vivo validation of ethnopharmacological uses of methanol extract of Isodon rugosus Wall. ex Benth. (Lamiaceae)
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The antispasmodic effect of Ometa cultivar shows that common gastrointestinal disorders could be treated by the functional food.
Effects of Ginkgo biloba Extract on the Oral Bioavailability of Fluoxetine and Venlafaxine in Rats
GK extract shows no physicochemical interactions with fluoxetine or venlafaxine, and the results showed that GK extract has no significant effects on the bioavailability of fluoxettine and venl Lafaxine.
Reversal of P‐glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole‐kindled and phenytoin‐treated mice
Treatment with G. biloba extract decreased seizure severity in pentylenetetrazole‐kindled/PHT‐treated mice through a mechanism that might be related to the reduction of P‐GP expression in the brain.
Evaluation of the Interactive Effects of Glycyrrhiza Glabra Hydroalcoholic Extract and LNAME Drug on Blood Pressure and Heart Rate of Male Rats
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[Pharmacokinetic properties of Bilobalide and Ginkgolides A and B in healthy subjects after intravenous and oral administration of Ginkgo biloba extract (EGb 761)].
The pharmacokinetics of GinkGolide A, Ginkgolide B and Bilobalide, which are compounds extracted from the dried leaves of the Ginkgo biloba tree, were investigated in 12 young healthy volunteers after single-dose administration of Ginkinggo Biloba extract.
Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level.
Quercetin, one of the ingredients in GBE, is suggested to be a principal ingredient of GBE producing vasodilation, which can activate nitric oxide synthesis and release by increasing [Ca2+]i in vascular endothelial cells.
Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.
GBE and bilobalide possess a similar characteristic for age-related modification, clinically suggesting the more effective actions of GBE for elder persons.
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.
This work has developed an efficient and rapid protocol for separation of individual ginkgolides and bilobalide from G. biloba extracts that takes advantage of enhanced susceptibility of ginkGolides B and C to benzylation and the ease of separation of these products from gink golides A and J which do not react.
Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract.
Results indicated that GBE-induced hepatic drug metabolizing enzymes in rats, especially CYPs, were rapidly recovered by discontinuation of GBE in rats even after excess treatment, and suggested that interactions of G BE with drugs could be avoided by discontinuated GBE.
Effects of chronic administration of bilobalide on amino acid levels in mouse brain.
Major increase in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), and glycine in the hippocampus of mice compared with the control and an increased level of glycine after bilobalide treatment was detected in the striatum.
Review about Ginkgo biloba special extract EGb 761 (Ginkgo).
A review of the current and past literature about older people with Alzheimer's dementia or vascular dementia or age-associated memory impairment treated with Ginkgo biloba extract, reveals that EGb has reproducible effects on cognitive functions in Alzheimer's disease.
Gastrointestinal receptors and drugs in motility disorders.
The review describes gastrointestinal receptors which are of therapeutic interest for the treatment of motility disorders and tries to point out the areas of particular need for further basic research and the prospects of further drug development.
The effect of muscarine on cholinoceptive neurones subserving the peristaltic reflex of guinea-pig isolated ileum
The results support the view that the cholinoceptive sites within the ganglia of the myenteric plexus subserving the peristaltic reflex have properties of both nicotinic and muscarinic receptors and suggest that the mechanism activated by these receptors differs from conventional synaptic transmission.
Identification of neurotransmitters regulating intestinal peristaltic reflex in humans.
  • J. Grider
  • Chemistry, Medicine
  • 1989
The components of the intestinal peristaltic reflex in humans were examined and the neurotransmitters responsible for them identified for the first time i isolated flat sheet segments of intestine, supporting the participation of vasoactive intestinal peptide motor neurons in descending relaxation and tachykinin motor neurons as well as cholinergicMotor neurons in ascending contraction.