Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation

  title={Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation},
  author={Dong Ryun Gu and Jin-Ki Hwang and Munkhsoyol Erkhembaatar and Kang-beom Kwon and Min Seuk Kim and Young-Rae Lee and Seoung-Hoon Lee},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
Chrysanthemum zawadskii Herbich var. [] Key Method latilobum Kitamura ethanol extract (CZE) on osteoclast differentiation induced by treatment with the receptor activator of NF- κ B ligand (RANKL). CZE inhibited osteoclast differentiation and formation in a dose-dependent manner. The inhibitory effect of CZE on osteoclastogenesis was due to the suppression of ERK activation and the ablation of RANKL-stimulated Ca(2+)-oscillation via the inactivation of PLC γ 2, followed by the inhibition of CREB activation…

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