Inhibitory Effect of Antioxidants on Hydroxyl Radical Generation from Methylguanidine: An ESR Study

@article{Noda2008InhibitoryEO,
  title={Inhibitory Effect of Antioxidants on Hydroxyl Radical Generation from Methylguanidine: An ESR Study},
  author={Yasuko Noda and Mitsumasa Mankura},
  journal={Neurochemical Research},
  year={2008},
  volume={34},
  pages={734-738}
}
Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (•OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K1 (α-tocopheryl-l-ascorbate-2-O-phosphate diester), Trolox (water-soluble vitamin E analogue), and glutathione (GSH) on •OH generation from MG using an electron spin resonance (ESR) spectrometry with spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO… CONTINUE READING

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