Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.

@article{Michel2013InhibitorsOV,
  title={Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.},
  author={Vera Michel and Yamhilette Lic{\'o}n-Mu{\~n}oz and Kristina A. Trujillo and Marco Bisoffi and Karlett J Parra},
  journal={International journal of cancer},
  year={2013},
  volume={132 2},
  pages={E1-10}
}
Vacuolar ATPases (V-ATPases) comprise specialized and ubiquitously distributed pumps that acidify intracellular compartments and energize membranes. To gain new insights into the roles of V-ATPases in prostate cancer (PCa), we studied the effects of inhibiting V-ATPase pumps in androgen-dependent (LNCaP) and androgen-independent (C4-2B) cells of a human PCa progression model. Treatment with nanomolar concentrations of the V-ATPase inhibitors bafilomycin A or concanamycin A reduced the in vitro… CONTINUE READING
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