Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.

Abstract

Urokinase-type plasminogen activator (uPA) seems to be an important protease in prostate cancer invasion, and tyrosine phosphorylation is thought to play a role in the regulation of its production. The amount of uPA was measured with a synthetic peptide substrate after treatment with various concentrations of tyrosine kinase inhibitors (TKI). The effect on… (More)

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@article{Skogseth2005InhibitorsOT, title={Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.}, author={Haakon R. Skogseth and Erik Larsson and Jostein Halgunset}, journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}, year={2005}, volume={113 5}, pages={332-9} }