Inhibitors of type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo.

@article{Hulley1995InhibitorsOT,
  title={Inhibitors of type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo.},
  author={P Hulley and J Hartikka and Samir Abdel'al and Peter Engels and H. R. B{\"u}rki and K. H. Wiederhold and Thomas Mueller and Patrick Kelly and David Lowe and Hermann Luebbert},
  journal={The European journal of neuroscience},
  year={1995},
  volume={7 12},
  pages={2431-40}
}
The neuropathology of Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra. We have recently shown that the activation of protein kinase A improves the survival of dopaminergic neurons in culture and, furthermore, protects them from the dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP+) in vitro. We have now analysed the potential of phosphodiesterase inhibitors to increase cAMP levels in dopaminergic neurons, to improve their… CONTINUE READING

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