Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.

@article{Jomaa1999InhibitorsOT,
  title={Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.},
  author={Hassan Jomaa and Jochen Wiesner and Silke Sanderbrand and Boran Altincicek and Claus Weidemeyer and Martin Hintz and Ivana Türbachova and Matthias Eberl and Johannes Zeidler and Hartmut K. Lichtenthaler and Dominique Soldati and Ewald Beck},
  journal={Science},
  year={1999},
  volume={285 5433},
  pages={
          1573-6
        }
}
A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria. This pathway includes 1-deoxy-D-xylulose 5-phosphate (DOXP) as a key metabolite. The presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprenoid biosynthesis in P. falciparum depends on the DOXP pathway. This pathway is probably located in the apicoplast. The recombinant P. falciparum… Expand

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