Inhibitors of the heat shock protein 90 : from cancer clinical trials to neurodegenerative diseases

@inproceedings{Peyrat2012InhibitorsOT,
  title={Inhibitors of the heat shock protein 90 : from cancer clinical trials to neurodegenerative diseases},
  author={Jean François Peyrat and Samir Messaoudi and Jean Daniel Brion and Mou{\^a}d Alami},
  year={2012}
}
The 90-kDa heat shock protein 90, Hsp90, belongs to the family of molecular chaperone responsible for the conformational maturation or reparation of other proteins, referred to as "clients", into biologically active structures (Pearl and Prodromou, 2006). Hsp90 exerts its essential ATP dependant chaperone function to more than three hundred client proteins involved in cell growth, differentiation and survival (Workman, 2004; Chiosis et al., 2004; Sreedhar et al., 2004b; Zhang and Burrows, 2004… CONTINUE READING

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