Inhibitors of the Tick-Borne, Hemorrhagic Fever-Associated Flaviviruses

@article{Flint2014InhibitorsOT,
  title={Inhibitors of the Tick-Borne, Hemorrhagic Fever-Associated Flaviviruses},
  author={M. Flint and L. McMullan and K. Dodd and B. Bird and M. Khristova and S. Nichol and C. Spiropoulou},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2014},
  volume={58},
  pages={3206 - 3216}
}
ABSTRACT No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). We tested compounds reported to have antiviral activity against members of the Flaviviridae family for their ability to inhibit AHFV replication. 6-Azauridine (6-azaU), 2′-C-methylcytidine (2′-CMC), and interferon alpha 2a (IFN-α2a… Expand
Nucleoside Inhibitors of Tick-Borne Encephalitis Virus
In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses.
Limited Effects of Type I Interferons on Kyasanur Forest Disease Virus in Cell Culture
...
1
2
3
4
...

References

SHOWING 1-10 OF 66 REFERENCES
Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses.
Tick-borne flaviviruses.
Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.
Evaluation of 6-Azauridine and S-Iododeoxyuridine in the Treatment of Experimental Viral Infections
Antiviral activity of nucleoside analogues against norovirus.
Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia.
Herpes Simplex Virus Skin Infection in Hairless Mice: Treatment with Antiviral Compounds
Alkhurma haemorrhagic fever--a viral haemorrhagic disease unique to the Arabian Peninsula.
...
1
2
3
4
5
...