Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents

@inproceedings{Cheah2014InhibitorsOT,
  title={Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents},
  author={Hong-Leong Cheah and Vuanghao Lim and Doblin Sandai},
  booktitle={PloS one},
  year={2014}
}
Candida albicans is an opportunistic pathogen that causes candidiasis in humans. In recent years, metabolic pathways in C. albicans have been explored as potential antifungal targets to treat candidiasis. The glyoxylate cycle, which enables C. albicans to survive in nutrient-limited host niches and its. Key enzymes (e.g., isocitrate lyase (ICL1), are particularly attractive antifungal targets for C. albicans. In this study, we used a new screening approach that better reflects the physiological… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

  • Journal of Chemical Information and Modeling
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Lead- and drug-like compounds: the rule-of-five revolution.

  • Drug discovery today. Technologies
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Biofilmgrown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species

H Van Acker, A Sass, S Bazzini, K De Roy, C Udine
  • PLoS ONE 8: e58943
  • 2013
VIEW 1 EXCERPT

Apigenin-induced suicidal erythrocyte death.

  • Journal of agricultural and food chemistry
  • 2012
VIEW 1 EXCERPT