Inhibitors of the GABA uptake systems

@article{KrogsgaardLarsen1980InhibitorsOT,
  title={Inhibitors of the GABA uptake systems},
  author={Povl Krogsgaard-Larsen},
  journal={Molecular and Cellular Biochemistry},
  year={1980},
  volume={31},
  pages={105-121}
}
This review describes a novel class of heterocyclic GABA uptake inhibitor with no affinity for the GABA receptors. The parent compound nipecotic acid is a potent inhibitor of neuronal and glial GABA uptake, and nipecotic acid is a substrate for the transport carriers concerned. The structurally related cyclic amino acids guvacine and cis-4-hydroxynipecotic acid are also potent inhibitors of both GABA transport systems. Even minor structural alterations of these compounds result in considerable… CONTINUE READING
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