Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor.

@article{SilvaSouza2014InhibitorsOT,
  title={Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor.},
  author={Hercules Ant{\^o}nio da Silva-Souza and Maria Nath{\'a}lia de Lira and Naman Kumar Patel and David C Spray and Pedro Muanis Persechini and Eliana Scemes},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={307 6},
  pages={
          C571-9
        }
}
A multitude of environmental signaling molecules influence monocyte and macrophage innate and adaptive immune responses, including ATP and prostanoids. Interestingly, purinergic (P2) and eicosanoid receptor signaling interact such that the activation of P2 receptors leads to prostanoid production, which can then interfere with P2Y-mediated macrophage migration. Recent studies suggest that blockade of 5-lipoxygenase (5-LOX) in macrophages can activate a permeation pathway involved in the influx… CONTINUE READING
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