Inhibitors of sclerostin: emerging concepts.

@article{Drake2014InhibitorsOS,
  title={Inhibitors of sclerostin: emerging concepts.},
  author={Matthew T Drake and Joshua Nicholas Farr},
  journal={Current opinion in rheumatology},
  year={2014},
  volume={26 4},
  pages={
          447-52
        }
}
PURPOSE OF REVIEW Recent data suggest that inhibitors of sclerostin, an osteocyte-produced Wnt signaling pathway antagonist, can stimulate bone formation. This review provides rationale and summarizes recent evidence supporting this novel approach to skeletal anabolism. RECENT FINDINGS Data from numerous preclinical models in rodents and monkeys consistently demonstrate that antisclerostin monoclonal antibody (Scl-Ab) treatment leads to improvements in bone mass and strength, as well as… CONTINUE READING
BETA
1
Twitter Mention