Inhibitors of receptor tyrosine kinases do not suppress progesterone-induced [Ca2+]i signalling in human spermatozoa.

@article{KirkmanBrown2002InhibitorsOR,
  title={Inhibitors of receptor tyrosine kinases do not suppress progesterone-induced [Ca2+]i signalling in human spermatozoa.},
  author={Jackson C. Kirkman-Brown and Linda Lefi{\`e}vre and Christopher Bray and P. M. Stewart and Christopher L. R. Barratt and Stephen John Publicover},
  journal={Molecular human reproduction},
  year={2002},
  volume={8 4},
  pages={326-32}
}
Previous studies have implicated receptor tyrosine kinases in progesterone-induced [Ca2+]i signalling, and consequent induction of the acrosome reaction, in human spermatozoa. We have investigated the effects of tyrosine kinase inhibition on [Ca2+]i responses in large numbers of individual human spermatozoa. Genistein (5, 50 and 250 micromol/l), an inhibitor of receptor-linked tyrosine kinases, significantly inhibited the progesterone-induced acrosome reaction (P < 0.05). However, we could… CONTINUE READING

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