Inhibitors of purine nucleoside phosphorylase, C(8) and C(5') substitutions.

@article{Stoeckler1982InhibitorsOP,
  title={Inhibitors of purine nucleoside phosphorylase, C(8) and C(5') substitutions.},
  author={J. Stoeckler and C. Cambor and V. Kuhns and S. Chu and R. Parks},
  journal={Biochemical pharmacology},
  year={1982},
  volume={31 2},
  pages={
          163-71
        }
}
Abstract The C(8) and C(5') positions of base and nucleoside substrates of human erythrocytic purine nucleoside phosphorylase (PNP) are promising sites for the development of an inhibitor of this enzyme. The substrate analog, 8-aminoguanine (8-AG), has the lowest dissociation constant ( K i = 0.2–1.2 μ M) of any compound reported to date and V max = 16 per cent (relative to guanine). Other C(8) substituents decreased the affinity for PNP and, with the exception of the methyl and sulfhydryl… Expand
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Allosteric regulation of purine nucleoside phosphorylase.
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