Inhibitors of polyamine biosynthesis block human cytomegalovirus replication

@article{Tyms1982InhibitorsOP,
  title={Inhibitors of polyamine biosynthesis block human cytomegalovirus replication},
  author={A Stanley Tyms and Jeff D. Williamson},
  journal={Nature},
  year={1982},
  volume={297},
  pages={690-691}
}
The antiviral activities of the few compounds available that are effective in the clinical treatment of virus infections are directed against nucleic acid synthesis1,2. Attention has been drawn recently to the need to develop new strategies, based on specific inhibitors of other biopolymers with essential functions in virus replication2. Polyamines may prove suitable targets, as these aliphatic bases are found in all animal cells, where they seem to have essential roles in the synthesis and… CONTINUE READING

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