Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.

@article{Genovese2005InhibitorsOP,
  title={Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.},
  author={Tiziana Genovese and Emanuela Mazzon and Carmelo Mui{\`a} and Nimesh S. A. Patel and Michael D. Threadgill and Placido Bramanti and Angelina De Sarro and Christoph Thiemermann and Salvatore Cuzzocrea},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={312 2},
  pages={
          449-57
        }
}
  • Tiziana Genovese, Emanuela Mazzon, +6 authors Salvatore Cuzzocrea
  • Published in
    The Journal of pharmacology…
    2005
  • Chemistry, Medicine
  • Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the tissue injury associated with stroke and neurotrauma. The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of spinal cord trauma, which was induced by the application of vascular clips (force of 24g) to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in mice resulted in severe trauma characterized… CONTINUE READING

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