Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.

@article{Zamzami1996InhibitorsOP,
  title={Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.},
  author={Naoufal Zamzami and Philippe Marchetti and Maria Castedo and Tamara Hirsch and Santos A Susin and Barbara Mass{\`e} and Guido Kroemer},
  journal={FEBS letters},
  year={1996},
  volume={384 1},
  pages={53-7}
}
In a number of experimental systems, the early stage of the apoptotic process, i.e. the stage which precedes nuclear disintegration, is characterized by the breakdown of the inner mitochondrial transmembrane potential (delta psi m). Here we address the question as to whether mitochondrial permeability transition (PT) pores may account for the delta psi m dissipation in lymphocyte apoptosis. Drugs known for their PT-inhibitory potential (bongkrekic acid, cyclosporin A, and the non… CONTINUE READING
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