Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by alpha-amino acid esters of phenethyl alcohols.

@article{Lindberg1978InhibitorsON,
  title={Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by alpha-amino acid esters of phenethyl alcohols.},
  author={U. H. Lindberg and S O Thorberg and Sophia Bengtsson and Anna L. Renyi and Svante B. Ross and Sven Ove {\"O}gren Ogren},
  journal={Journal of medicinal chemistry},
  year={1978},
  volume={21 5},
  pages={448-56}
}
A series of alpha-amino acid esters of substituted phenethyl alcohols was prepared and tested as inhibitors of the neuronal reuptake of noradrenaline and 5-hydroxytryptamine. Some of the compounds are potent and very selective in blocking the 5-hydroxytryptamine uptake, as evidenced by biochemical data and behavioral tests. The most promising agent, alaproclate [2-(4-chlorophenyl)-1,1-dimethylethyl 2-aminopropanoate hydrochloride (I, IV)], was selected for further studies as a potential… CONTINUE READING
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