Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials.

  title={Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials.},
  author={Carlotta Granchi and Simone Bertini and Marco Macchia and Filippo Minutolo},
  journal={Current medicinal chemistry},
  volume={17 7},
In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic glycolysis, by catalyzing the reduction of pyruvate into lactate. This enzyme has recently received a great deal of attention since it may constitute a valid therapeutic target for diseases so different as malaria and cancer. In fact, the isoform expressed by Plasmodium falciparum (pfLDH) is a key enzyme for energy generation of malarial parasites. These species mostly depend on anaerobic… CONTINUE READING

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