Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids.

Abstract

A series of 2-substituted inosine monophosphate (IMP) and inosine derivatives were synthesized and tested for inhibitory activity against IMP dehydrogenase from Escherichia coli. All of the IMP analogues that possessed electron-withdrawing substituents on the phenyl ring of a benzylthio group placed at the 2-position of IMP showed strong inhibition, which… (More)

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@article{Wong1984InhibitorsOI, title={Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids.}, author={C. G. Wong and R. B. Meyer}, journal={Journal of medicinal chemistry}, year={1984}, volume={27 4}, pages={429-32} }