Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.

@article{Huber2011InhibitorsOH,
  title={Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.},
  author={Kelly D. Huber and Genevi{\`e}ve Doyon and Joseph G Plaks and Elizabeth Fyne and John W Mellors and Nicolas Sluis-Cremer},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 25},
  pages={22211-8}
}
Deacetylation of histone proteins at the HIV type 1 (HIV-1) long terminal repeat (LTR) by histone deactylases (HDACs) can promote transcriptional repression and virus latency. As such, HDAC inhibitors (HDACI) could be used to deplete reservoirs of persistent, quiescent HIV-1 proviral infection. However, the development of HDACI to purge latent HIV-1 requires knowledge of the HDAC isoforms contributing to viral latency and the development of inhibitors specific to these isoforms. In this study… CONTINUE READING

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Reactivation of latent HIV-1 in J89GFP cells by varying concentrations (0 –10 mM) of valproic acid. The percentage of J89GFP cells expressing EGFP was quantitated after 24 h by FACs

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