Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat.

Abstract

We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesser degree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.

Cite this paper

@article{Westerberg1987InhibitorsOH, title={Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat.}, author={Vern Westerberg and Jonathan Geiger}, journal={Pharmacology, biochemistry, and behavior}, year={1987}, volume={28 3}, pages={419-22} }