Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.

@article{Perni2003InhibitorsOH,
  title={Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.},
  author={Robert B. Perni and Shawn D Britt and J. M. C. Court and Lawrence F Courtney and David Deininger and Luc J Farmer and Cynthia A Gates and Scott L Harbeson and Joseph L Kim and James A Landro and Rhonda B Levin and Y P Luong and Ethan T O'Malley and J{\'a}nos Pitlik and B. G. Rao and Wayne C. Schairer and J. Arthur Thomson and Roger D Tung and John H Van Drie and Yunyi Wei},
  journal={Bioorganic & medicinal chemistry letters},
  year={2003},
  volume={13 22},
  pages={4059-63}
}
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.