Inhibitors of hepatitis B virus attachment and entry.

@article{Lempp2014InhibitorsOH,
  title={Inhibitors of hepatitis B virus attachment and entry.},
  author={Florian A. Lempp and Stephan Urban},
  journal={Intervirology},
  year={2014},
  volume={57 3-4},
  pages={151-7}
}
Inhibition of virus entry has become a major concept in the development of new antiviral drugs. Entry inhibitors can either neutralize activities of viral surface proteins or target essential host factors such as (co)receptors. Due to its distinct tissue tropism and the highly specific viral and cellular factors involved in its entry, hepatitis B virus (HBV) is an ideal candidate for entry inhibition. Hepatitis B immunoglobulins neutralize infection by binding to the S-domain of HBV surface… CONTINUE READING