Inhibitors of guanidinobenzoatase and their possible role in cell migration.

Guanidinobenzoatase is a cell surface protease associated with cells capable of migration, this enzyme is trypsin-like and cleaves the link peptide Gly-Arg-Gly-Asp of fibronectin. A fluorescent probe, 9-aminoacridine, has been used to locate cells possessing guanidinobenzoatase by fluorescent microscopy. 9-aminoacridine is a competitive inhibitor of this… CONTINUE READING