Inhibitors of glutathione S-transferases as therapeutic agents.

Abstract

Glutathione S-transferases (GST) are a family of phase II detoxification enzymes with broad substrate specificities. They catalyze the conjugation of glutathione with many different types of xenobiotics, rendering the compound more water soluble and thus more easily eliminated. Resistance to cancer chemotherapeutic drugs, such as the alkylating agents, has… (More)

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Cite this paper

@article{Tew1997InhibitorsOG, title={Inhibitors of glutathione S-transferases as therapeutic agents.}, author={Tew and P Dutta and R Schultz}, journal={Advanced drug delivery reviews}, year={1997}, volume={26 2-3}, pages={91-104} }