Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain

@inproceedings{Fazzari2015InhibitorsOG,
  title={Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain},
  author={Jennifer Fazzari and Hanxin Lin and Cecilia Murphy and Robert G. Ungard and Gurmit Singh},
  booktitle={Scientific reports},
  year={2015}
}
Glutamate is an important signaling molecule in a wide variety of tissues. Aberrant glutamatergic signaling disrupts normal tissue homeostasis and induces several disruptive pathological conditions including pain. Breast cancer cells secrete high levels of glutamate and often metastasize to bone. Exogenous glutamate can disrupt normal bone turnover and may be responsible for cancer-induced bone pain (CIBP). CIBP is a significant co-morbidity that affects quality of life for many advanced-stage… CONTINUE READING