Inhibitors of ergosterol biosynthesis and growth of the trypanosomatid protozoan Crithidia fasciculata.

@article{RAHMAN1990InhibitorsOE,
  title={Inhibitors of ergosterol biosynthesis and growth of the trypanosomatid protozoan Crithidia fasciculata.},
  author={MOHD. DZUR A. RAHMAN and Robert A Pascal},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 9},
  pages={4989-96}
}
Six nitrogen-, sulfur- and cyclopropane-containing derivatives of cholestanol were examined as inhibitors of growth and sterol biosynthesis in the trypanosomatid protozoan Crithidia fasciculata. The concentrations of inhibitors in the culture medium required for 50% inhibition of growth were 0.32 microM for 24-thia-5 alpha,20 xi-cholestan-3 beta-ol (2), 0.009 microM for 24-methyl-24-aza-5 alpha,20 xi-cholestan-3 beta-ol (3), 0.95 microM for (20,21),(24,-25)-bis-(methylene)-5 alpha,20 xi… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…