Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.

@article{Kauser1991InhibitorsOC,
  title={Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.},
  author={K. Kauser and J. Clark and B. Masters and P. Ortiz de Montellano and Y. H. Ma and D. Harder and R. Roman},
  journal={Circulation research},
  year={1991},
  volume={68 4},
  pages={
          1154-63
        }
}
The role of cytochrome P-450 in the myogenic response of isolated, perfused renal arcuate arteries of dogs to elevations in transmural pressure was examined. The phospholipase A2 inhibitor oleyloxyethylphosphorylcholine (1 and 10 microM) inhibited the greater than threefold increase in active wall tension in these arteries after an elevation in perfusion pressure from 80 to 160 mm Hg. Inhibition of cyclooxygenase activity with indomethacin (1 or 10 microM) had no effect on this response. The… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Presence of cytochrome P-450-dependent monooxygenase in intimal cells of the hog aorta.
TLDR
The localization of cytochrome P-450-dependent mixed function oxidase primarily to the intimal surface of the aorta may indicate a role for this enzyme system in vasoregulation and the pathogenesis of atherosclerosis. Expand
Cytochrome P450-dependent arachidonate metabolism in renomedullary cells: formation of Na+K+-ATPase inhibitor.
TLDR
A cytochrome P450-dependent mono-oxygenase system which metabolizes arachidonic acid to two biologically active oxygenated peaks, each containing two or more products, and formation of these oxygenated arachidonate metabolites is stimulated by arginine vasopressin and salmon calcitonin. Expand
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
A new generation of heteroatom analogs of arachidonic acid are documented as powerful and selective inhibitors of the cytochrome P-450-dependent arachidonic acid oxygenase reaction (IC50, 5-10Expand
Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites.
TLDR
Results support the hypothesis that AA can be the source of a novel class of nonprostaglandin vasodilator compounds and suggest that cytochrome P450 products might be vasoactive mediators in injured tissue. Expand
Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium.
  • D. Harder
  • Biology, Medicine
  • Circulation research
  • 1987
TLDR
The data document a dependence of an intact endothelium in mediating the activation of isolated cat cerebral arteries in response to a changing transmural pressure, and suggest that the endothelial cell may serve as a transducer in the autoregulatory response to pressure. Expand
Mechanism of Action of EDRF on Pressurized Arteries: Effect on K+ Conductance
TLDR
The hypothesis that the EDRF-induced hyperpolarization is mediated, at least in part, by an increase in K conductance is supported. Expand
Pressure Releases a Transferable Endothelial Contractile Factor in Cat Cerebral Arteries
TLDR
The EDRF antagonist oxyhemoglobin did not alter the excitatory response to pressure in these isolated cerebral arteries further suggesting that the reduction in diameter and muscle cell depolarization results from the release of a contractile substance from the vascular endothelium and not inhibition of EDRf. Expand
Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries.
TLDR
It is found and confirmed by gas chromatography/mass spectrometry that primarily 12- and 15-hydroxyeicosatetraenoic acids (HETEs) are synthesized by both coronary artery segments, and the synthesis of these metabolites is greater in the stenosed, endothelially injured vessel. Expand
Mechanisms of pressure-induced myogenic activation of cerebral and renal arteries: role of the endothelium.
TLDR
The way in which increases in transmural pressure within the physiological range can activate cerebral and renal vascular muscle by depolarizing the muscle cell membrane is studied. Expand
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
TLDR
EETs are a labile class of vasodilators with a potency comparable to adenosine in the intestinal microcirculation and indirect evidence suggests regional differences in the formation of vasoactive quantities of arachidonate metabolites within the intestinal wall. Expand
...
1
2
3
4
5
...