Inhibitors of cyclooxygenases: mechanisms, selectivity and uses.

  • R. M. Botting
  • Published 2006 in
    Journal of physiology and pharmacology : an…


The prostaglandins are lipid mediators, discovered in the 1930s by von Euler in Sweden and Goldblatt in the United Kingdom. They are made by the bifunctional enzyme, cyclooxygenase, which has both cyclooxygenase and peroxidase activities in the same molecule. Prostaglandins are involved in physiological functions such as protection of the stomach mucosa… (More)