Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.

Abstract

Immortal human fibroblasts isolated following transfection with thermolabile simian virus 40 T antigen lost division potential upon shift up in temperature due to heat inactivation of the antigen. Such cells showed a concomitant change in the distribution of a mortality marker, mortalin, from a juxtanuclear cap like distribution of immortal cells to a… (More)

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@article{Fujii1995InhibitorsOC, title={Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.}, author={M. Fujii and Tomomi Ide and Rishi Kumar Wadhwa and Hiroyuki Tahara and Sunil C. Kaul and Y. Mitsui and T. Ogata and M. Oishi and Dai Ayusawa}, journal={Oncogene}, year={1995}, volume={11 4}, pages={627-34} }