Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.

@article{Seefeld2001InhibitorsOB,
  title={Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.},
  author={Mark A. Seefeld and William H. Miller and Kenneth A Newlander and Walter J Burgess and David J Payne and Stephen F Rittenhouse and Terrance Moore and Walter E. deWolf and Paul M. Keller and Xiayang Qiu and Cheryl A. Janson and Kalindi S Vaidya and Andrew P. Fosberry and M. G. G. Smyth and Deborah D Jaworski and Courtney Slater-Radosti and William F Huffman},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 17},
  pages={2241-4}
}
An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI).