Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains.

  title={Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains.},
  author={Monique Mall{\'e}a and Jacqueline Chevalier and Annie Eyraud and Jean-Marie Pag{\'e}s},
  journal={Biochemical and biophysical research communications},
  volume={293 5},
Enterobacter aerogenes, a nosocomial pathogen, is frequently exhibiting multidrug resistance mechanisms associated with a change in membrane permeability. In clinical isolates, active efflux plays a prominent role in antibiotic resistance. We report here the effect of three unrelated compounds that are able to restore a noticeable antibiotic susceptibility to resistant strains. The targeting of various parameters which contribute to the efficacy of the efflux mechanism, such as energy, flux… CONTINUE READING
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