Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation.

@article{Duramad2005InhibitorsOT,
  title={Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation.},
  author={Omar Duramad and Karen L. Fearon and Bonnie Chang and Jean H. Chan and Josh G Gregorio and Robert Lee Coffman and Franck J Barrat},
  journal={Journal of immunology},
  year={2005},
  volume={174 9},
  pages={5193-200}
}
In parallel with the discovery of the immunostimulatory activities of CpG-containing oligodeoxynucleotides, several groups have reported specific DNA sequences that could inhibit activation by CpG-containing oligodeoxynucleotides in mouse models. We show that these inhibitory sequences, termed IRS, inhibit TLR-9-mediated activation in human as well as mouse cells. This inhibitory activity includes proliferation and IL-6 production by B cells, and IFN-alpha and IL-12 production by plasmacytoid… CONTINUE READING

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