Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo.

@article{Ouyang2006InhibitorsOR,
  title={Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo.},
  author={Bin Ouyang and Jeffrey A. Knauf and Eric L. P. Smith and Lei Zhang and Tim Ramsey and Naeem Yusuff and David Batt and James A. Fagin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 6},
  pages={1785-93}
}
PURPOSE Papillary thyroid carcinomas are associated with nonoverlapping activating mutations of RET, NTRK, RAS and BRAF, which altogether are present in approximately 70% of cases. We postulated that compounds that inhibit a distal effector in the mitogen-activated protein kinase (MAPK) pathway would inhibit growth and tumorigenicity of human thyroid cancer cell lines with mutations of RET or BRAF. EXPERIMENTAL DESIGN AND RESULTS We first examined the effects of AAL-881 and LBT-613, two… CONTINUE READING
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BRAF mediates RET / PTCinduced MAPK activation in thyroid cells : functional support for requirement of the RET / PTCRASBRAF pathway in papillary thyroid carcinogenesis

  • N Mitsutake, M Miyagishi, M Mitsutake
  • Endocrinology
  • 2006

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